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DMT11
Lieutenant Junior Grade
Joined: Aug 30, 2018
Member#: 8599
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 Posted:
Fri Aug 31, 2018 9:22 pm Post subject: detoxification of carcinogens |
 
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SAN FRANCISCO, Dec. 27 (Xinhua) -- Researchers with Oregon State University (OSU) have identified a protein, Nrf2, that is behind the breakdown in genetic communication causing syndromes associated with aging.
Nrf2 helps regulate gene expression and the body's reaction to various types of stressors.
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When it finds a problem, Nrf2 goes back to the cellular nucleus and rings the alarm bell, where it can ""turn on"" up to 200 genes that are responsible for cell repair puma rihanna bianche , detoxification of carcinogens, protein and lipid metabolism, antioxidant protection and other actions. About half of Nrf2 is used up every 20 minutes as it performs life-protective functions.
Metabolic insults routinely increase with age, and if things were working properly, the amount of Nrf2 that goes back into the nucleus should also increase to help deal with those insults. However puma rihanna nere e oro , the level of nuclear Nrf2 declines with age.
""The levels of Nrf2, and the functions associated with it, are routinely about 30-40 percent lower in older laboratory animals,"" said Kate Shay, director of the Healthy Aging Core Laboratory at OSU and co-author on the study. ""We've been able to show for the first time what we believe is the cause.""
The researchers point to the increasing levels of a micro-RNA known as miRNA-146a.
Micro-RNAs help play a major role in genetic signaling puma rihanna nere punta oro , controlling what genes are ""expressed,"" or turned on and off to perform the. |
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